Risperidone half-life in a patient taking paroxetine -- a case report. Article uri icon

Overview

abstract

  • This case report further establishes the inhibitory effects of paroxetine on risperidone (R) metabolism in a patient whose R was discontinued due to side effects. Baseline through levels in ng/ml were 33 for R, 9 for 9-hydroxyrisperidone (9-OHR) and 42 for the total moiety. The fourth morning after R discontinuation, levels were 4 for R, 1 for 9-OHR and 5 for the total moiety. The estimated half-lives were 23.8 hours for R, 22.8 hours for 9-OHR and 23.5 hours for the total moiety.

publication date

  • September 1, 2005

Research

keywords

  • Antidepressive Agents, Second-Generation
  • Inactivation, Metabolic
  • Paroxetine

Identity

Scopus Document Identifier

  • 26244457406

Digital Object Identifier (DOI)

  • 10.1055/s-2005-873159

PubMed ID

  • 16189751

Additional Document Info

volume

  • 38

issue

  • 5