Characterization of polyclonal antibodies raised against a linear peptide determinant of desmoglein-3. Academic Article uri icon

Overview

abstract

  • Our labs are pursueing the goal of exactly defining the qualities of peptide antigenicity, immunogenicity and pathogenicity in order to develop safe specific immunotherapies by utilizing specific portions of disease-associated-proteins (DAPs). Using as a model the Pemphigus vulgaris antigen (PVA) desmoglein 3 (Dsg3), we have studied the murine humoral response against the Dsg3 amino acid 49-60 peptide sequence, previously characterized as sequence having low similarity to the mouse proteome. The results show that the low-similarity Dsg3(49-60)REWVKFAKPCRE peptide does not elicit pathogenic antibodies.

publication date

  • January 1, 2005

Research

keywords

  • Antibodies
  • Desmogleins
  • Pemphigus

Identity

Scopus Document Identifier

  • 23044474907

PubMed ID

  • 16416595

Additional Document Info

volume

  • 5

issue

  • 1