Peptide-based biomaterials for protease-enhanced drug delivery. Academic Article uri icon

Overview

abstract

  • Controlled delivery of drugs in response to environments has the potential of targeting therapies and personalized treatments. Here, we described self-assembled peptide sequences that release therapeutic payloads upon specific interaction with disease-associated proteases. The core peptide sequence consists of a protease cleavable region flanked by two self-assembly motifs. In aqueous solution, the peptides self-assemble as a gel scaffold. With treatment of the model preparations with the appropriate protease, the matrix can be degraded in a controlled fashion, where the degradation rate is fine-tuned by varying the peptide compositions. Protease-mediated drug release was demonstrated by enzymatic treatment of a model therapeutic peptide incorporated into the optimized matrix. Our results suggest that this type of material may have far-reaching applications for functionally targeted drug delivery.

publication date

  • April 1, 2006

Research

keywords

  • Biocompatible Materials
  • Peptides

Identity

Scopus Document Identifier

  • 33646358709

PubMed ID

  • 16602747

Additional Document Info

volume

  • 7

issue

  • 4