Heat shock protein-90 inhibitors: a chronicle from geldanamycin to today's agents. Review uri icon

Overview

abstract

  • Heat shock protein (Hsp)90 is a chaperone with essential roles in maintaining transformation and in elevating the survival and growth potential of cancer cells. The recognition of Hsp90 as an important target in cancer therapy has prompted the identification, development and clinical translation of a large array of Hsp90 inhibitors. This review discusses the modalities that may interfere with this chaperone's function and describes the status of existing and emerging Hsp90 inhibitor classes.

publication date

  • June 1, 2006

Research

keywords

  • Antineoplastic Agents
  • HSP90 Heat-Shock Proteins
  • Neoplasms

Identity

Scopus Document Identifier

  • 33745174538

PubMed ID

  • 16784024

Additional Document Info

volume

  • 7

issue

  • 6