Brainstem primitive neuroectodermal tumors (bstPNET): results of treatment with intensive induction chemotherapy followed by consolidative chemotherapy with autologous hematopoietic cell rescue. Academic Article uri icon

Overview

abstract

  • We have evaluated the response rate and survival utilizing intensified chemotherapy followed by myeloablative chemotherapy with autologous hematopoietic cell rescue (AuHCR) and adjuvant radiation therapy in six young children with newly diagnosed brainstem primitive neuroectodermal tumors (bstPNET). Following maximum surgical resection of the tumor, patients received high dose induction chemotherapy including vincristine, cisplatin, cyclophosphamide, and etoposide. Eligible patients received a single cycle of myeloablative chemotherapy followed by AuHCR. Two patients survive at least 32 months with stable disease. This approach provides an alternative for young patients with bstPNET who in prior reports have had a uniformly fatal prognosis.

publication date

  • March 1, 2008

Research

keywords

  • Antineoplastic Combined Chemotherapy Protocols
  • Bone Marrow Transplantation
  • Brain Stem
  • Infratentorial Neoplasms
  • Neuroectodermal Tumors, Primitive
  • Peripheral Blood Stem Cell Transplantation

Identity

Scopus Document Identifier

  • 38549182369

PubMed ID

  • 17009232

Additional Document Info

volume

  • 50

issue

  • 3