The use of perfusion CT for the evaluation of therapy combining AZD2171 with gefitinib in cancer patients. Academic Article uri icon

Overview

abstract

  • The purpose of this study was to determine the feasibility of dynamic contrast-enhanced perfusion CT (CTP) in evaluating the hemodynamic response of tumors in the chest and abdomen treated with a combination of AZD2171 and gefitinib. Thirteen patients were examined just before and every 4-6 weeks after starting therapy. Following intravenous injection of a contrast agent, dynamic image acquisition was obtained at the level of a selected tumor location. To calculate perfusion, the maximum-slope method was used. Pre-treatment average perfusion for extra-hepatic masses was 84 ml/min/100 g, for liver masses arterial perfusion was 25 ml/min/100 g, and a portal perfusion of 30 ml/min/100 g was found. After the administration of AZD2171 and gefitinib, in extra-hepatic masses an initial decrease in perfusion of 18% was followed by a plateau and in liver masses an initial decrease of 39% within the lesions and of 36% within a rim region surrounding the lesions was followed by a tendency to recovery of hepatic artery flow. In conclusion, CTP is feasible in showing changes of perfusion induced by anti-angiogenic therapy.

publication date

  • October 27, 2006

Research

keywords

  • Angiography
  • Antineoplastic Combined Chemotherapy Protocols
  • Image Processing, Computer-Assisted
  • Mediastinal Neoplasms
  • Pancreatic Neoplasms
  • Pelvic Neoplasms
  • Pleural Neoplasms
  • Quinazolines
  • Tomography, Spiral Computed

Identity

Scopus Document Identifier

  • 34250315281

PubMed ID

  • 17072618

Additional Document Info

volume

  • 17

issue

  • 7