Congenital corneal opacities: a review with a focus on genetics. Review uri icon

Overview

abstract

  • Congenital corneal opacities present in approximately 3/100,000 newborns. Many different disorders may result in corneal opacifications of infancy, including Peters' anomaly (PA), congenital hereditary endothelial dystrophy (CHED), congenital hereditary stromal dystrophy (CHSD) and posterior polymorphous dystrophy (PPMD). Current studies have localized defects using genetic testing in PA, CHED, CHSD and PPMD. Identifying mutations for specific disorders may lead to better understanding of the underlying pathogeneses and may help with diagnosis and prognosis. This article will review the clinical presentations, treatments and genetics of Peters' anomaly, congenital hereditary endothelial dystrophy, congenital hereditary stromal dystrophy and posterior polymorphous dystrophy.

publication date

  • October 1, 2007

Research

keywords

  • Corneal Opacity

Identity

Scopus Document Identifier

  • 37549047240

PubMed ID

  • 18097987

Additional Document Info

volume

  • 22

issue

  • 4