Safety of real-time convection-enhanced delivery of liposomes to primate brain: a long-term retrospective. Academic Article uri icon

Overview

abstract

  • Convection-enhanced delivery (CED) is gaining popularity in direct brain infusions. Our group has pioneered the use of liposomes loaded with the MRI contrast reagent as a means to track and quantitate CED in the primate brain through real-time MRI. When co-infused with therapeutic nanoparticles, these tracking liposomes provide us with unprecedented precision in the management of infusions into discrete brain regions. In order to translate real-time CED into clinical application, several important parameters must be defined. In this study, we have analyzed all our cumulative animal data to answer a number of questions as to whether real-time CED in primates depends on concentration of infusate, is reproducible, allows prediction of distribution in a given anatomic structure, and whether it has long term pathological consequences. Our retrospective analysis indicates that real-time CED is highly predictable; repeated procedures yielded identical results, and no long-term brain pathologies were found. We conclude that introduction of our technique to clinical application would enhance accuracy and patient safety when compared to current non-monitored delivery trials.

publication date

  • December 27, 2007

Research

keywords

  • Brain
  • Convection
  • Drug Delivery Systems
  • Liposomes
  • Macaca fascicularis

Identity

PubMed Central ID

  • PMC2362104

Scopus Document Identifier

  • 41149091077

Digital Object Identifier (DOI)

  • 10.1016/j.expneurol.2007.12.015

PubMed ID

  • 18295759

Additional Document Info

volume

  • 210

issue

  • 2