Postoperative intensity-modulated radiation therapy for cancers of the paranasal sinuses, nasal cavity, and lacrimal glands: technique, early outcomes, and toxicity. Academic Article uri icon

Overview

abstract

  • BACKGROUND: Our aim was to review Memorial Sloan-Kettering Cancer Center's experience with postoperative intensity-modulated radiotherapy (IMRT) for paranasal sinus, nasal cavity, and lacrimal gland cancer and report dosimetric measures, toxicity, and outcomes. METHODS: Between September 2000 and June 2006, 37 patients with paranasal sinus, nasal cavity, or lacrimal gland cancer underwent postoperative IMRT. Median values were as follows: prescription dose, 60 Gy (range, 50-70); PTV(D95), 99% (range, 79-101%); optic nerve Dmax, 53 Gy (range, 2-54); optic chiasm Dmax, 51Gy (range, 2-55). Acute and late toxicities were scored by Radiation Therapy Oncology Group morbidity criteria. RESULTS: Median follow-up was 28 months. Two-year local progression-free and overall survivals were 75% and 80%. No early- or late-grade 3/4 radiation-induced ophthalmologic toxicity occurred. CONCLUSIONS: Preliminary results show that adjuvant IMRT in these patients is feasible, allowed for excellent planning target volume (PTV) coverage, and minimized dose delivered to optic structures. Longer follow-up is warranted to assess the extent of late effects and outcomes.

publication date

  • July 1, 2008

Research

keywords

  • Eye Neoplasms
  • Nose Neoplasms
  • Paranasal Sinus Neoplasms
  • Radiotherapy Planning, Computer-Assisted
  • Radiotherapy, Intensity-Modulated

Identity

Scopus Document Identifier

  • 47549086975

Digital Object Identifier (DOI)

  • 10.1002/hed.20800

PubMed ID

  • 18302261

Additional Document Info

volume

  • 30

issue

  • 7