Imaging and dosimetry of 99mTc EC annexin V: preliminary clinical study targeting apoptosis in breast tumors. Academic Article uri icon

Overview

abstract

  • BACKGROUND: Early detection of cellular events is important to predict the outcome of the patients. This study was aimed to use (99m)Tc EC-annexin V to image tumor cells undergoing apoptosis. METHODS: In 10 patients with breast cancer, scintigraphic images and dosimetric estimates were obtained after administering (99m)Tc EC-annexin V. RESULTS: Nine of the 10 cases showed detectable (99m)Tc EC-annexin V uptake in tumor. Higher values of T/N ratios are associated with patient after treatment. CONCLUSIONS: Apoptosis can be quantified using (99m)Tc EC-annexin V.

publication date

  • January 26, 2008

Research

keywords

  • Annexin A5
  • Apoptosis
  • Breast Neoplasms
  • Organotechnetium Compounds

Identity

PubMed Central ID

  • PMC2562036

Scopus Document Identifier

  • 47749122924

Digital Object Identifier (DOI)

  • 10.1016/j.apradiso.2008.01.012

PubMed ID

  • 18308577

Additional Document Info

volume

  • 66

issue

  • 9