Severe iron overload with a novel aminolevulinate synthase mutation and hepatitis C infection. A case report. Academic Article uri icon



  • A 55 year old man with a history of chronic hepatitis C infection was found to have severe hemochromatosis: hepatic cirrhosis, cardiomyopathy, arrhythmia, hypogonadism, diabetes and bronzed skin color. After 50 phlebotomies, he underwent a combined heart and liver transplant. Genetic analyses identified a novel mutation in the iron responsive element of the ALAS2 gene. No mutations were found in other genes associated with adult or juvenile hemochromatosis including HFE, transferrin receptor-2 (TFR2), ferroportin (SLC40A1), hepcidin (HAMP) and hemojuvelin (HJV). We suggest that the ALAS2 mutation together with chronic hepatitis C infection may have caused the severe iron overload phenotype.

publication date

  • September 26, 2008



  • 5-Aminolevulinate Synthetase
  • Hepatitis C, Chronic
  • Iron Overload


PubMed Central ID

  • PMC2696479

Scopus Document Identifier

  • 57949084602

Digital Object Identifier (DOI)

  • 10.1016/j.bcmd.2008.08.001

PubMed ID

  • 18823803

Additional Document Info


  • 42


  • 1