Shigella targets the mitochondrial checkpoint of programmed necrosis. uri icon

Overview

abstract

  • In nonmyeloid cells, Shigella hijacks the mitochondrial checkpoint of cell death, thereby inducing a regulated form of necrosis depending on Bnip3 and cyclophilin D. Carneiro et al. (2009) describe the interplay between this program and a prosurvival response transmitted via the Nod1/Rip2/NF-kappaB/Bcl-2 axis, which determines the fate of infected cells.

publication date

  • February 19, 2009

Research

keywords

  • Apoptosis
  • Epithelial Cells
  • Mitochondria
  • Shigella

Identity

Scopus Document Identifier

  • 60649096938

Digital Object Identifier (DOI)

  • 10.1016/j.chom.2009.01.002

PubMed ID

  • 19218080

Additional Document Info

volume

  • 5

issue

  • 2