Inherited predisposition to gastrointestinal stromal tumor. Review uri icon

Overview

abstract

  • Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors of the gastrointestinal tract and are a relatively recently identified category of mesenchymal tumors. Germline mutations in a number of different genes predispose to GIST. This article discusses familial GIST syndrome, Carney triad, Carney-Stratakis syndrome, and neurofibromatosis type 1, and addresses the recognition of an inherited predisposition in GIST patients.

publication date

  • February 1, 2009

Research

keywords

  • Gastrointestinal Stromal Tumors
  • Proto-Oncogene Proteins c-kit
  • Receptor, Platelet-Derived Growth Factor alpha

Identity

Scopus Document Identifier

  • 60549083675

Digital Object Identifier (DOI)

  • 10.1016/j.hoc.2008.12.003

PubMed ID

  • 19248967

Additional Document Info

volume

  • 23

issue

  • 1