Molecular mechanisms of mTOR-mediated translational control. Review uri icon

Overview

abstract

  • The process of translation requires substantial cellular resources. Cells have therefore evolved complex mechanisms to control overall protein synthesis as well as the translation of specific mRNAs that are crucial for cell growth and proliferation. At the heart of this process is the mammalian target of rapamycin (mTOR) signalling pathway, which senses and responds to nutrient availability, energy sufficiency, stress, hormones and mitogens to modulate protein synthesis. Here, we highlight recent findings on the regulators and effectors of mTOR and discuss specific cases that serve as paradigms for the different modes of mTOR regulation and its control of translation.

publication date

  • April 2, 2009

Research

keywords

  • Gene Expression Regulation
  • Protein Kinases

Identity

Scopus Document Identifier

  • 67349217986

Digital Object Identifier (DOI)

  • 10.1038/nrm2672

PubMed ID

  • 19339977

Additional Document Info

volume

  • 10

issue

  • 5