Phase III randomised study of dexamethasone with or without oblimersen sodium for patients with advanced multiple myeloma. Academic Article uri icon



  • Upregulation of the Bcl-2 antiapoptotic protein is reported to be associated with aggressive clinical course in multiple myeloma. Oblimersen sodium is a bcl-2 antisense oligonucleotide complementary to the first six codons of the open-reading frame of bcl-2 mRNA that can decrease transcription of Bcl-2 protein and increase myeloma cell susceptibility to cytotoxic agents. In this phase III randomised trial, we investigated in patients with relapsed/refractory myeloma whether addition of oblimersen to dexamethasone improved clinical outcomes vs. dexamethasone alone. Two hundred and twenty-four patients were randomised to receive either oblimersen/dexamethasone (N = 110) or dexamethasone alone (N = 114). The primary endpoint was time to tumor progression (TTP). Final results of this study demonstrated no significant differences between the two groups in TTP or objective response rate. The oblimersen/dexamethasone regimen was generally well tolerated with fatigue, fever and nausea, the most common adverse events reported.

publication date

  • April 1, 2009



  • Antineoplastic Combined Chemotherapy Protocols
  • Dexamethasone
  • Multiple Myeloma


Scopus Document Identifier

  • 68449085118

Digital Object Identifier (DOI)

  • 10.1080/10428190902748971

PubMed ID

  • 19373653

Additional Document Info


  • 50


  • 4