T cell infiltrate predicts long-term survival following resection of colorectal cancer liver metastases. Academic Article uri icon

Overview

abstract

  • BACKGROUND: While tumor infiltrating lymphocytes (TIL) have been shown to independently predict survival in primary colorectal cancer, the prognostic implications of TIL in resectable colorectal cancer liver metastases (CRCLM) have not been previously defined. This study examines the correlation between TIL numbers and survival following hepatic resection. METHODS: We studied patients who survived or=10 years following CRCLM resection. Immunohistochemistry was performed on tissue microarrays (TMAs) to determine the number of T cells within CRCLM. Correlation between TIL frequency and or=10 year survival was determined while controlling for established prognostic factors. RESULTS: Of 162 patients, 104 survived or=10 years. Independent correlates of 10-year survival following CRCLM resection included a high number of CD8 T cells, a low number of CD4 T cells, and a clinical risk score of

publication date

  • July 1, 2009

Research

keywords

  • Colorectal Neoplasms
  • Liver Neoplasms
  • Lymphocytes, Tumor-Infiltrating

Identity

Scopus Document Identifier

  • 68949204170

Digital Object Identifier (DOI)

  • 10.1245/s10434-009-0585-3

PubMed ID

  • 19568816

Additional Document Info

volume

  • 16

issue

  • 9