Relationship of vitamin D and parathyroid hormone with obesity and body composition in African Americans.
Academic Article
Overview
abstract
BACKGROUND: Obesity disproportionately affects African Americans (AA) (especially women), and is linked to depressed 25-hydroxyvitamin D (25-OH D) and elevated parathyroid hormone (PTH). The relationship of 25-OH D and PTH with body composition and size in AA is not well known. OBJECTIVE: To determine the relationship of 25-OH D and PTH levels with body composition and anthropometric measures. DESIGN: A cross-sectional study was conducted in 98 healthy, overweight, adult AA enrolled in an NIH/NIEHS-sponsored weight loss/salt-sensitivity trial. MEASUREMENTS: Multivariable linear regression analyses were used to explore the relationship of 25-OH D and PTH with body composition, determined by dual-energy X-ray absorptiometry, and anthropometric measures. Body composition and size were contrasted across vitamin D/PTH groups using general linear models: (i) normal (25-OH D >50 nmol/l, PTH
