Immortalized human brain endothelial cell line HCMEC/D3 as a model of the blood-brain barrier facilitates in vitro studies of central nervous system infection by Cryptococcus neoformans. Academic Article uri icon

Overview

abstract

  • Cryptococcus neoformans cells must cross the blood-brain barrier prior to invading the central nervous system. Here we demonstrate that the immortalized human brain endothelial cell line HCMEC/D3 is a useful alternative to primary brain endothelial cells as a model of the blood-brain barrier for studies of central nervous system infection.

publication date

  • September 18, 2009

Research

keywords

  • Blood-Brain Barrier
  • Brain
  • Central Nervous System Infections
  • Cryptococcosis
  • Cryptococcus neoformans
  • Endothelial Cells

Identity

PubMed Central ID

  • PMC2772405

Scopus Document Identifier

  • 72449202243

Digital Object Identifier (DOI)

  • 10.1128/EC.00240-09

PubMed ID

  • 19767445

Additional Document Info

volume

  • 8

issue

  • 11