A case of adult metastatic Xp11 translocation renal cell carcinoma treated successfully with sunitinib. uri icon

Overview

abstract

  • Renal cell carcinomas (RCC) associated with Xp11.2 translocations (transcription factor E3 gene fusions) are rare tumors predominantly reported in children. Although only a small number of adult Xp11.2 translocation RCC cases have been described, this is likely due to the possibility of this tumor being unrecognized because of its histologic similarity to either clear cell or papillary subtypes based on hematoxylin and eosin staining. Herein, we describe the first successful case of systemic treatment of metastatic Xp11 RCC with sunitinib, a currently accepted standard of care in metastatic RCC, and attempt to elucidate potential mechanisms behind sunitinib activity in this histologic subtype.

publication date

  • October 1, 2009

Research

keywords

  • Antineoplastic Agents
  • Carcinoma, Renal Cell
  • Chromosomes, Human, Pair 11
  • Chromosomes, Human, X
  • Indoles
  • Kidney Neoplasms
  • Pyrroles
  • Translocation, Genetic

Identity

Scopus Document Identifier

  • 70449087190

Digital Object Identifier (DOI)

  • 10.3816/CGC.2009.n.031

PubMed ID

  • 19815489

Additional Document Info

volume

  • 7

issue

  • 3