Clathrin and AP1B: key roles in basolateral trafficking through trans-endosomal routes. Review uri icon

Overview

abstract

  • Research following introduction of the MDCK model system to study epithelial polarity (1978) led to an initial paradigm that posited independent roles of the trans Golgi network (TGN) and recycling endosomes (RE) in the generation of, respectively, biosynthetic and recycling routes of plasma membrane (PM) proteins to apical and basolateral PM domains. This model dominated the field for 20 years. However, studies over the past decade and the discovery of the involvement of clathrin and clathrin adaptors in protein trafficking to the basolateral PM has led to a new paradigm. TGN and RE are now believed to cooperate closely in both biosynthetic and recycling trafficking routes. Here, we critically review these recent advances and the questions that remain unanswered.

publication date

  • October 23, 2009

Research

keywords

  • Adaptor Protein Complex 1
  • Clathrin
  • Endosomes

Identity

PubMed Central ID

  • PMC4286365

Scopus Document Identifier

  • 70450214034

Digital Object Identifier (DOI)

  • 10.1016/j.febslet.2009.10.050

PubMed ID

  • 19854182

Additional Document Info

volume

  • 583

issue

  • 23