In-vivo quantification of wall motion in cerebral aneurysms from 2D cine phase contrast magnetic resonance images. Academic Article uri icon

Overview

abstract

  • PURPOSE: The quantification of wall motion in cerebral aneurysms is of interest for the assessment of aneurysmal rupture risk, for providing boundary conditions for computational simulations and as a validation tool for theoretical models. MATERIALS AND METHODS: 2D cine phase contrast magnetic resonance imaging (2D pcMRI) in combination with quantitative magnetic resonance angiography (QMRA) was evaluated for measuring wall motion in 7 intracranial aneurysms. In each aneurysm, 2 (in one case 3) cross sections, oriented approximately perpendicular to each other, were measured. RESULTS: The maximum aneurysmal wall distention ranged from 0.16 mm to 1.6 mm (mean 0.67 mm), the maximum aneurysmal wall contraction was -1.91 mm to -0.34 mm (mean 0.94 mm), and the average wall displacement ranged from 0.04 mm to 0.31 mm (mean 0.15 mm). Statistically significant correlations between average wall displacement and the shape of inflow curves (p-value < 0.05) were found in 7 of 15 cross sections; statistically significant correlations between the displacement of the luminal boundary center point and the shape of inflow curves (p-value < 0.05) were found in 6 of 15 cross sections. CONCLUSION: 2D pcMRI in combination with QMRA is capable of visualizing and quantifying wall motion in cerebral aneurysms. However, application of this technique is currently restricted by its limited spatial resolution.

publication date

  • October 26, 2009

Research

keywords

  • Cerebral Angiography
  • Image Enhancement
  • Image Processing, Computer-Assisted
  • Imaging, Three-Dimensional
  • Intracranial Aneurysm
  • Magnetic Resonance Angiography
  • Magnetic Resonance Imaging, Cine
  • Muscle, Smooth, Vascular
  • Vasoconstriction
  • Vasodilation

Identity

Scopus Document Identifier

  • 76649091591

Digital Object Identifier (DOI)

  • 10.1055/s-0028-1109670

PubMed ID

  • 19859863

Additional Document Info

volume

  • 182

issue

  • 2