Candidate genetic analysis of plasma high-density lipoprotein-cholesterol and severity of coronary atherosclerosis. Academic Article uri icon

Overview

abstract

  • BACKGROUND: Plasma level of high-density lipoprotein-cholesterol (HDL-C), a heritable trait, is an important determinant of susceptibility to atherosclerosis. Non-synonymous and regulatory single nucleotide polymorphisms (SNPs) in genes implicated in HDL-C synthesis and metabolism are likely to influence plasma HDL-C, apolipoprotein A-I (apo A-I) levels and severity of coronary atherosclerosis. METHODS: We genotyped 784 unrelated Caucasian individuals from two sets of populations (Lipoprotein and Coronary Atherosclerosis Study- LCAS, N = 333 and TexGen, N = 451) for 94 SNPs in 42 candidate genes by 5' nuclease assays. We tested the distribution of the phenotypes by the Shapiro-Wilk normality test. We used Box-Cox regression to analyze associations of the non-normally distributed phenotypes (plasma HDL-C and apo A-I levels) with the genotypes. We included sex, age, body mass index (BMI), diabetes mellitus (DM), and cigarette smoking as covariates. We calculated the q values as indicators of the false positive discovery rate (FDR). RESULTS: Plasma HDL-C levels were associated with sex (higher in females), BMI (inversely), smoking (lower in smokers), DM (lower in those with DM) and SNPs in APOA5, APOC2, CETP, LPL and LIPC (each q

publication date

  • October 30, 2009

Research

keywords

  • Cholesterol, HDL
  • Coronary Artery Disease
  • Genetic Association Studies

Identity

PubMed Central ID

  • PMC2775733

Scopus Document Identifier

  • 70749098299

Digital Object Identifier (DOI)

  • 10.1186/1471-2350-10-111

PubMed ID

  • 19878569

Additional Document Info

volume

  • 10