Technical challenges associated with the radiolabeling of monoclonal antibodies utilizing short-lived, positron emitting radionuclides. Review uri icon

Overview

abstract

  • Many factors, both physical and chemical, affect the radiolabeling of a chemical compound. These factors add a new dimension of complexity when the labeling of monoclonal antibodies is attempted with short-lived, positron emitting radionuclides. A lack of appreciation for the unique chemical separations associated with the radionuclide incorporated into the synthetic precursor can often lead to unexpected or non-reproducible results.

publication date

  • January 1, 1991

Research

keywords

  • Antibodies, Monoclonal
  • Iodine Radioisotopes
  • Isotope Labeling

Identity

Scopus Document Identifier

  • 44949284277

PubMed ID

  • 2010313

Additional Document Info

volume

  • 18

issue

  • 1