Inflammation, innate immunity and blood coagulation. Review uri icon

Overview

abstract

  • Inflammation drives arterial, venous and microvascular thrombosis. Chronic inflammation contributes to arterial thrombotic complications, whereas acute inflammation drives venous thrombosis and microvascular thrombosis. Mechanistically, inflammation modulates thrombotic responses by upregulating procoagulants, downregulating anticoagulants and suppressing fibrinolysis. The inflammatory response can also result in cell apoptosis or necrosis. Products released from the dead cells, particularly histones, propagate further inflammation, tissue death and organ failure. Inhibition of histone mediated cytotoxicity appears to be a new mechanism for protecting against this deadly cascade.

publication date

  • January 1, 2010

Research

keywords

  • Blood Coagulation
  • Immunity, Innate
  • Inflammation

Identity

Scopus Document Identifier

  • 77949305755

PubMed ID

  • 20162248

Additional Document Info

volume

  • 30

issue

  • 1