Gastroesophageal reflux disease and obesity. Review uri icon

Overview

abstract

  • Gastroesophageal reflux disease (GERD) is a common condition, with multifactorial pathogenesis, affecting up to 40% of the population. Obesity is also common. Obesity and GERD are clearly related, both from a prevalence and causality association. GERD symptoms increase in severity when people gain weight. Obese patients tend to have more severe erosive esophagitis and obesity is a risk factor for the development of Barrett's esophagus and adenocarcinoma of the esophagus. Patients report improvement in GERD when they lose weight and there are several reports suggesting a decrease in GERD symptoms after bariatric surgery. At present, there is little evidence that obesity has any effect on the efficacy of antisecretory therapy, with conflicting data on surgical outcomes. This review attempts to put in perspective the relationship of these two common entities.

publication date

  • March 1, 2010

Research

keywords

  • Gastroesophageal Reflux
  • Obesity

Identity

Scopus Document Identifier

  • 77349125186

Digital Object Identifier (DOI)

  • 10.1016/j.gtc.2009.12.002

PubMed ID

  • 20202577

Additional Document Info

volume

  • 39

issue

  • 1