abstract
- A structure-activity relationship study was carried out on a series of thiohydantoins and their analogues 14 which led to the discovery of 92 (MDV3100) as the clinical candidate for the treatment of hormone refractory prostate cancer.
Structure-activity relationship for thiohydantoin androgen receptor antagonists for castration-resistant prostate cancer (CRPC).
Academic Article
Overview
authors
publication date
- April 8, 2010
published in
- Journal of medicinal chemistry Journal
Research
keywords
- Androgen Receptor Antagonists
- Orchiectomy
- Prostatic Neoplasms
- Thiohydantoins
Identity
PubMed Central ID
- PMC3180999
Scopus Document Identifier
- 77950574393
Digital Object Identifier (DOI)
- 10.1021/jm901488g
PubMed ID
- 20218717
Additional Document Info
has global citation frequency
volume
- 53
issue
- 7