Cell signaling in protein synthesis ribosome biogenesis and translation initiation and elongation. Review uri icon

Overview

abstract

  • Protein synthesis is a highly energy-consuming process that must be tightly regulated. Signal transduction cascades respond to extracellular and intracellular cues to phosphorylate proteins involved in ribosomal biogenesis and translation initiation and elongation. These phosphorylation events regulate the timing and rate of translation of both specific and total mRNAs. Alterations in this regulation can result in dysfunction and disease. While many signaling pathways intersect to control protein synthesis, the mTOR and MAPK pathways appear to be key players. This chapter briefly reviews the mTOR and MAPK pathways and then focuses on individual phosphorylation events that directly control ribosome biogenesis and translation.

publication date

  • October 27, 2009

Research

keywords

  • Cells
  • Peptide Chain Elongation, Translational
  • Peptide Chain Initiation, Translational
  • Ribosomes
  • Signal Transduction

Identity

Scopus Document Identifier

  • 77956697347

Digital Object Identifier (DOI)

  • 10.1016/S1877-1173(09)90002-3

PubMed ID

  • 20374739

Additional Document Info

volume

  • 90