NF-kappaB signaling modulation by EBV and KSHV. Review uri icon

Overview

abstract

  • The nuclear factor (NF)-kappaB signaling pathway is pivotal for immune system function. Not surprisingly, pathogenic microorganisms have developed strategies to subvert it. Two examples are Epstein-Barr virus (EBV) and Kaposi sarcoma herpesvirus (KSHV), oncogenic gammaherpesviruses that establish a lifelong latent infection in their human hosts. The modulation of NF-kappaB signaling by EBV and KSHV is not only important for viral infection, but also contributes to the development of malignant neoplasia. This review explores the current knowledge of NF-kappaB modulation by EBV and KSHV, focusing on connections between viral biology and human carcinogenesis.

publication date

  • May 6, 2010

Research

keywords

  • Cell Transformation, Neoplastic
  • Herpesviridae Infections
  • Herpesvirus 4, Human
  • Herpesvirus 8, Human
  • NF-kappa B
  • Neoplasms
  • Signal Transduction

Identity

Scopus Document Identifier

  • 78049508529

Digital Object Identifier (DOI)

  • 10.1016/j.tim.2010.04.001

PubMed ID

  • 20452220

Additional Document Info

volume

  • 18

issue

  • 6