Evidence for the involvement of Lfc and Tctex-1 in axon formation. Academic Article uri icon

Overview

abstract

  • RhoA and Rac play key and opposite roles during neuronal polarization. We now show that Lfc, a guanosine nucleotide exchange factor (GEF), localizes to the Golgi apparatus and growth cones of developing neurons and negatively regulates neurite sprouting and axon formation through a Rho signaling pathway. Tctex-1, a dynein light chain implicated in axon outgrowth by modulating actin dynamics and Rac activity, colocalizes and physically interacts with Lfc, thus inhibiting its GEF activity, decreasing Rho-GTP levels, and functionally antagonizing Lfc during neurite formation.

publication date

  • May 12, 2010

Research

keywords

  • Axons
  • Dyneins
  • Guanine Nucleotide Exchange Factors

Identity

PubMed Central ID

  • PMC3845415

Scopus Document Identifier

  • 77952342061

Digital Object Identifier (DOI)

  • 10.1523/JNEUROSCI.5420-09.2010

PubMed ID

  • 20463241

Additional Document Info

volume

  • 30

issue

  • 19