High frequency oscillation in patients with acute lung injury and acute respiratory distress syndrome (ARDS): systematic review and meta-analysis. Review uri icon

Overview

abstract

  • OBJECTIVE: To determine clinical and physiological effects of high frequency oscillation compared with conventional ventilation in patients with acute lung injury/acute respiratory distress syndrome (ARDS). DESIGN: Systematic review and meta-analysis. DATA SOURCES: Electronic databases to March 2010, conference proceedings, bibliographies, and primary investigators. STUDY SELECTION: Randomised controlled trials of high frequency oscillation compared with conventional ventilation in adults or children with acute lung injury/ARDS. Data selection Three authors independently extracted data on clinical, physiological, and safety outcomes according to a predefined protocol. We contacted investigators of all included studies to clarify methods and obtain additional data. Analyses used random effects models. RESULTS: Eight randomised controlled trials (n=419 patients) were included; almost all patients had ARDS. Methodological quality was good. The ratio of partial pressure of oxygen to inspired fraction of oxygen at 24, 48, and 72 hours was 16-24% higher in patients receiving high frequency oscillation. There were no significant differences in oxygenation index because mean airway pressure rose by 22-33% in patients receiving high frequency oscillation (P

publication date

  • May 18, 2010

Research

keywords

  • Acute Lung Injury
  • High-Frequency Ventilation
  • Respiratory Distress Syndrome

Identity

Scopus Document Identifier

  • 77953693966

Digital Object Identifier (DOI)

  • 10.1136/bmj.c2327

PubMed ID

  • 20483951

Additional Document Info

volume

  • 340