Physiological carbon dioxide, bicarbonate, and pH sensing. Review uri icon

Overview

abstract

  • In biological systems, carbon dioxide exists in equilibrium with bicarbonate and protons. The individual components of this equilibrium (i.e., CO₂, HCO₃⁻, and H(+)), which must be sensed to be able to maintain cellular and organismal pH, also function as signals to modulate multiple physiological functions. Yet, the molecular sensors for CO₂/HCO₃⁻/pH remained unknown until recently. Here, we review recent progress in delineating molecular and cellular mechanisms for sensing CO₂, HCO₃⁻, and pH.

publication date

  • August 4, 2010

Research

keywords

  • Bicarbonates
  • Carbon Dioxide

Identity

PubMed Central ID

  • PMC2967379

Scopus Document Identifier

  • 78549266789

Digital Object Identifier (DOI)

  • 10.1007/s00424-010-0865-6

PubMed ID

  • 20683624

Additional Document Info

volume

  • 460

issue

  • 6