RARγ is required for correct deposition and removal of Suz12 and H2A.Z in embryonic stem cells. Academic Article uri icon

Overview

abstract

  • Retinoic acid (RA) induces embryonic stem cell differentiation. The effects of RA are mediated by retinoic acid receptors (RARs) that promote epigenetic changes controlling gene transcription. We show here that RARγ, in the absence of the ligand RA, is required for deposition of the histone variant H2A.Z and the polycomb group protein Suz12 at RA target genes, and that in embryonic stem cells both RARγ and Suz12 exist in a multi-protein complex in the absence of ligand. Addition of RA causes removal of H2A.Z and Suz12 from RARγ target genes when the genes are transcriptionally activated.

publication date

  • February 1, 2011

Research

keywords

  • Embryonic Stem Cells
  • Histones
  • Receptors, Retinoic Acid
  • Repressor Proteins

Identity

PubMed Central ID

  • PMC3369573

Scopus Document Identifier

  • 78649668803

Digital Object Identifier (DOI)

  • 10.1002/jcp.22420

PubMed ID

  • 20857416

Additional Document Info

volume

  • 226

issue

  • 2