Treatment of lisch corneal dystrophy with photorefractive keratectomy and mitomycin C. uri icon

Overview

abstract

  • PURPOSE: To describe a case of Lisch dystrophy; review the clinical, histopathologic, and electron microscopic features of this entity; and discuss a novel treatment approach using photorefractive keratectomy (PRK) and mitomycin C (MMC). METHODS: A 45-year-old man with a feathery, comet-shaped, right-sided, corneal lesion was treated with excimer laser PRK and 20 seconds of MMC. The uninvolved fellow eye underwent traditional PRK without the use of MMC. Epithelial scrapings were sent for histopathologic analysis. RESULTS: Histopathologic analysis showed vacuolated cells in the epithelial layer. Electron microscopy revealed empty intracytoplasmic vacuoles, electron-dense whorled inclusions, and reduced tonofilaments. Surface ablation and MMC was successful in treating the initial lesion, with only minimal recurrence noted in the affected eye. Surprisingly, a new asymptomatic lesion was noted in the unaffected eye but dissipated over time. CONCLUSIONS: Although the whorled inclusions represent a novel finding, the overall clinical and microscopic analysis was consistent with Lisch dystrophy. Surface ablation with MMC should be considered as a treatment option for this disease.

publication date

  • April 1, 2011

Research

keywords

  • Alkylating Agents
  • Corneal Dystrophies, Hereditary
  • Lasers, Excimer
  • Mitomycin
  • Photorefractive Keratectomy

Identity

Scopus Document Identifier

  • 79952989006

Digital Object Identifier (DOI)

  • 10.1097/ICO.0b013e3181ec8e26

PubMed ID

  • 21045666

Additional Document Info

volume

  • 30

issue

  • 4