Metabolism of apolipoproteins A-I and A-II and its influence on the high density lipoprotein subfraction distribution in males and females. Academic Article uri icon

Overview

abstract

  • Rate zonal ultracentrifugation of plasma samples from ten healthy age-matched volunteers (five males, five females) indicated that the high density lipoprotein subfraction ratio (HDL2:HDL3) in females was significantly higher than in males. The cause of this phenomenon was investigated by simultaneous examination of the metabolism of the major HDL apoproteins (apoA-I and apoA-II) in both groups. The results show that there is no significant sex-related difference in the plasma pool size, fractional catabolic rate, or synthetic rate of either apoprotein. We conclude that the increased HDL2:HDL3 ratio in femalse versus males does not derive from measurable differences in the metabolic handling of either apoprotein.

publication date

  • June 1, 1978

Research

keywords

  • Apolipoproteins
  • Lipoproteins, HDL

Identity

Scopus Document Identifier

  • 0018139663

PubMed ID

  • 211035

Additional Document Info

volume

  • 8

issue

  • 3