Anti-cytokine therapies for psoriasis. Review uri icon

Overview

abstract

  • Current approaches for the treatment of psoriasis with anti-cytokine therapies involve the blockade of TNF-α, or the p40 sub-unit of IL-12 and IL-23. However, the field is currently evolving to test more selective antagonists, such as anti-IL-23p19, IL-17 and other inflammatory cytokines. Here we discuss our current understanding of dendritic cell and T cell subsets that are relevant in psoriasis, and the pharmacologic strategies that temper their activity in this disease.

publication date

  • February 4, 2011

Research

keywords

  • Antibodies
  • Cytokines
  • Psoriasis

Identity

Scopus Document Identifier

  • 79955646735

Digital Object Identifier (DOI)

  • 10.1016/j.yexcr.2011.01.024

PubMed ID

  • 21300061

Additional Document Info

volume

  • 317

issue

  • 9