Reanalysis of coreceptor tropism in HIV-1-infected adults using a phenotypic assay with enhanced sensitivity. Academic Article uri icon

Overview

abstract

  • The enhanced-sensitivity Trofile assay (TF-ES; Monogram Biosciences) was used to retest coreceptor tropism samples from 4 different cohorts of HIV-1-infected patients. Nine percent to 26% of patients with CCR5-tropic virus by the original Trofile assay had CXCR4-using virus by TF-ES. Lower CD4 cell counts were associated with CXCR4-using virus in all cohorts.

publication date

  • April 1, 2011

Research

keywords

  • HIV Infections
  • HIV-1
  • Receptors, HIV
  • Viral Tropism
  • Virology
  • Virus Attachment

Identity

PubMed Central ID

  • PMC3106234

Scopus Document Identifier

  • 79953742964

Digital Object Identifier (DOI)

  • 10.1093/cid/cir072

PubMed ID

  • 21427401

Additional Document Info

volume

  • 52

issue

  • 7