G-quadruplex RNA structure as a signal for neurite mRNA targeting. Academic Article uri icon

Overview

abstract

  • Targeting of messenger RNAs (mRNAs) in neuron processes relies on cis-acting regulatory elements, the nature of which is poorly understood. Here, we report that approximately 30% of the best-known dendritic mRNAs contain a guanine (G)-quadruplex consensus in their 3'-untranslated region. Among these mRNAs, we show by using RNA structure probing that a G-quadruplex is present in the mRNAs of two key postsynaptic proteins: PSD-95 and CaMKIIa. The G-quadruplex structure is necessary and sufficient for the potent and fast localization of mRNAs in cortical neurites and this occurs in a metabotropic glutamate receptor-responsive manner. Thus, G-quadruplex seems to be a common neurite localization signal.

publication date

  • July 1, 2011

Research

keywords

  • G-Quadruplexes
  • Neurites
  • Nucleic Acid Conformation
  • RNA, Messenger

Identity

PubMed Central ID

  • PMC3128965

Scopus Document Identifier

  • 79959923521

Digital Object Identifier (DOI)

  • 10.1038/embor.2011.76

PubMed ID

  • 21566646

Additional Document Info

volume

  • 12

issue

  • 7