Modern concepts in the biology, diagnosis, differential diagnosis and treatment of primary central nervous system lymphoma. Review uri icon

Overview

abstract

  • Recent studies addressing the molecular characteristics of PCNSL, which is defined as malignant B-cell lymphoma with morphological features of DLBCL, have significantly improved our understanding of the pathogenesis of this lymphoma entity, which is associated with an inferior prognosis as compared with DLBCL outside the CNS. This unfavorable prognosis stimulated intense efforts to improve therapy and induced recent series of clinical studies, which addressed the role of radiotherapy and various chemotherapeutic regimens. This review combines the discussion of diagnosis, differential diagnosis and recent progress in studies addressing the molecular pathogenesis as well as therapeutic options in PCNSL.

publication date

  • August 5, 2011

Research

keywords

  • Central Nervous System Neoplasms

Identity

Scopus Document Identifier

  • 83555174950

Digital Object Identifier (DOI)

  • 10.1038/leu.2011.169

PubMed ID

  • 21818113

Additional Document Info

volume

  • 25

issue

  • 12