Predictors of survival in patients with recurrent ovarian cancer undergoing secondary cytoreductive surgery based on the pooled analysis of an international collaborative cohort. Academic Article uri icon

Overview

abstract

  • BACKGROUND: This study aims to identify prognostic factors and to develop a risk model predicting survival in patients undergoing secondary cytoreductive surgery (SCR) for recurrent epithelial ovarian cancer. METHODS: Individual data of 1100 patients with recurrent ovarian cancer of a progression-free interval at least 6 months who underwent SCR were pooled analysed. A simplified scoring system for each independent prognostic factor was developed according to its coefficient. Internal validation was performed to assess the discrimination of the model. RESULTS: Complete SCR was strongly associated with the improvement of survival, with a median survival of 57.7 months, when compared with 27.0 months in those with residual disease of 0.1-1 cm and 15.6 months in those with residual disease of >1 cm, respectively (P<0.0001). Progression-free interval (≤23.1 months vs >23.1 months, hazard ratio (HR): 1.72; score: 2), ascites at recurrence (present vs absent, HR: 1.27; score: 1), extent of recurrence (multiple vs localised disease, HR: 1.38; score: 1) as well as residual disease after SCR (R1 vs R0, HR: 1.90, score: 2; R2 vs R0, HR: 3.0, score: 4) entered into the risk model. CONCLUSION: This prognostic model may provide evidence to predict survival benefit from secondary cytoreduction in patients with recurrent ovarian cancer.

authors

  • Zang, R Y
  • Harter, P
  • Chi, Dennis
  • Sehouli, J
  • Jiang, R
  • Tropé, C G
  • Ayhan, A
  • Cormio, G
  • Xing, Y
  • Wollschlaeger, K M
  • Braicu, E I
  • Rabbitt, C A
  • Oksefjell, H
  • Tian, W J
  • Fotopoulou, C
  • Pfisterer, J
  • du Bois, A
  • Berek, J S

publication date

  • August 30, 2011

Research

keywords

  • Adenocarcinoma, Clear Cell
  • Adenocarcinoma, Mucinous
  • Cystadenocarcinoma, Serous
  • Endometrial Neoplasms
  • Neoplasm Recurrence, Local
  • Ovarian Neoplasms
  • Ovariectomy

Identity

PubMed Central ID

  • PMC3185944

Scopus Document Identifier

  • 80053242297

Digital Object Identifier (DOI)

  • 10.1038/bjc.2011.328

PubMed ID

  • 21878937

Additional Document Info

volume

  • 105

issue

  • 7