Tumor entrained neutrophils inhibit seeding in the premetastatic lung. Academic Article uri icon

Overview

abstract

  • Primary tumors have been shown to prepare distal organs for later colonization of metastatic cells by stimulating organ-specific infiltration of bone marrow derived cells. Here we demonstrate that neutrophils accumulate in the lung prior to the arrival of metastatic cells in mouse models of breast cancer. Tumor-entrained neutrophils (TENs) inhibit metastatic seeding in the lungs by generating H(2)O(2) and tumor secreted CCL2 is a critical mediator of optimal antimetastatic entrainment of G-CSF-stimulated neutrophils. TENs are present in the peripheral blood of breast cancer patients prior to surgical resection but not in healthy individuals. Thus, whereas tumor-secreted factors contribute to tumor progression at the primary site, they concomitantly induce a neutrophil-mediated inhibitory process at the metastatic site.

publication date

  • September 13, 2011

Research

keywords

  • Breast Neoplasms
  • Lung
  • Lung Neoplasms
  • Neutrophils

Identity

PubMed Central ID

  • PMC3172582

Scopus Document Identifier

  • 80052566377

Digital Object Identifier (DOI)

  • 10.1016/j.ccr.2011.08.012

PubMed ID

  • 21907922

Additional Document Info

volume

  • 20

issue

  • 3