Recent advances in single molecule studies of nucleosomes. Review uri icon

Overview

abstract

  • As the fundamental packing units of DNA in eukaryotes, nucleosomes play a central role in governing DNA accessibility in a variety of cellular processes. Our understanding of the mechanisms underlying this complex regulation has been aided by unique structural and dynamic perspectives offered by single molecule techniques. Recent years have witnessed remarkable advances achieved using these techniques, including the generation of a detailed histone-DNA energy landscape, elucidation of nucleosome disassembly processes, and real-time monitoring of molecular motors interacting with nucleosomes. These and other highlights of single molecule nucleosome studies will be discussed in this review.

publication date

  • December 13, 2011

Research

keywords

  • Nucleosomes

Identity

PubMed Central ID

  • PMC5515226

Scopus Document Identifier

  • 84857034648

Digital Object Identifier (DOI)

  • 10.1016/j.sbi.2011.11.003

PubMed ID

  • 22172540

Additional Document Info

volume

  • 22

issue

  • 1