Implications of Identifying Additional Cerebral Metastases during Gamma Knife Radiosurgery. Academic Article uri icon

Overview

abstract

  • Introduction. Gamma Knife radiosurgery (GK-SRS) is commonly used to treat cerebral metastases. Although additional intracranial metastases are often found on the day of GK-SRS, the significance of finding them is unknown. Methods. A retrospective review of 133 patients undergoing GK-SRS for cerebral metastases was performed. The change in number of metastases detected between initial referral magnetic resonance imaging (MRI) and subsequent treatment MRI was quantified. Multivariate and Kaplan-Meier analyses were employed to examine the significance of identifying additional lesions. Results. Additional lesions were identified in 41% of patients. An increasing number of metastases on referral MRI (P = 0.001) and the presence of progressive systemic disease (P = 0.003) were predictive of identifying additional metastases. Median survival was 6.9 months for patients with additional metastases, compared to 12.1 months for patients without additional metastases (hazard ratio 1.56, P = 0.021). Conclusions. Identifying additional metastases on the day of GK-SRS may add important prognostic information.

publication date

  • August 15, 2011

Identity

PubMed Central ID

  • PMC3265271

Scopus Document Identifier

  • 84863882818

Digital Object Identifier (DOI)

  • 10.1155/2012/748284

PubMed ID

  • 22312543

Additional Document Info

volume

  • 2012