Outcomes of HIV-infected patients treated for recurrent tuberculosis with the standard retreatment regimen. Academic Article uri icon

Overview

abstract

  • SETTING: The Groupe Haitien d'Etude du Sarcome de Kaposi et des Infections Opportunistes (the GHESKIO AIDS and TB Center) in Port-au-Prince, Haiti. OBJECTIVE: To measure the effectiveness of the standard TB retreatment regimen (2HRZES/1HRZE/5HRE) in human immunodeficiency virus (HIV) infected adults. DESIGN: Cohort study. RESULTS: Of 1318 HIV-infected patients with access to antiretroviral therapy following World Health Organization guidelines, 56 were diagnosed with recurrent pulmonary TB and retreated with the standard retreatment regimen: 10 patients (18%) died during retreatment, 3 (5%) defaulted, and 2 (4%) failed treatment. Forty-one patients (73%) achieved retreatment 'success' (cure, treatment completed). Of these, 8 (20%) died during follow-up, 5 (12%) were lost, and 5 (12%) had a second recurrence of TB. Only 26 (46%) of the 56 patients remained alive, in care, and TB-free after a median of 36 months of follow-up. CONCLUSION: HIV-infected patients treated for recurrent TB with the standard retreatment regimen have high mortality and poor long-term outcomes.

publication date

  • April 9, 2012

Research

keywords

  • AIDS-Related Opportunistic Infections
  • Anti-HIV Agents
  • Antitubercular Agents
  • Coinfection
  • HIV Infections
  • Tuberculosis, Pulmonary

Identity

PubMed Central ID

  • PMC3676909

Scopus Document Identifier

  • 84861127042

Digital Object Identifier (DOI)

  • 10.5588/ijtld.11.0210

PubMed ID

  • 22507948

Additional Document Info

volume

  • 16

issue

  • 6