Nongenomic Mechanisms of PTEN Regulation. Academic Article uri icon

Overview

abstract

  • A large amount of data supports the view that PTEN is a bona fide tumor suppressor gene. However, recent evidence suggests that derailment of cellular localization and expression levels of functional nonmutated PTEN is a determining force in inducing abnormal cellular and tissue outcomes. As the cellular mechanisms that regulate normal PTEN enzymatic activity resolve, it is evident that deregulation of these mechanisms can alter cellular processes and tissue architecture and ultimately lead to oncogenic transformation. Here we discuss PTEN ubiquitination, PTEN complex formation with components of the adherens junction, PTEN nuclear localization, and microRNA regulation of PTEN as essential regulatory mechanisms that determine PTEN function independent of gene mutations and epigenetic events.

publication date

  • March 25, 2012

Identity

PubMed Central ID

  • PMC3320059

Scopus Document Identifier

  • 84859755905

Digital Object Identifier (DOI)

  • 10.1155/2012/379685

PubMed ID

  • 22536248

Additional Document Info

volume

  • 2012