Collision in the inferior olive: hypertrophic olivary degeneration complicated by radiation necrosis in brainstem primitive neuroendocrine tumor. Academic Article uri icon



  • Hypertrophic olivary degeneration (HOD) is caused by disruption of the triangle of Guillain and Mollaret. We describe a child with a primitive neuroendocrine tumor who developed an expansile nonenhancing lesion in the olive after surgery and radiation therapy. Diffusion tensor imaging and tractography showed disruption of the central tegmental tract consistent with HOD. Subsequent transient enhancement of the olive was consistent with early radiation injury. Knowledge of coexisting complications such as HOD and radiation injury is essential for proper management.

publication date

  • June 8, 2012



  • Brain Stem Neoplasms
  • Nerve Degeneration
  • Neuroendocrine Tumors
  • Olivary Nucleus
  • Radiation Injuries
  • Radiotherapy, Intensity-Modulated


PubMed Central ID

  • PMC4728139

Scopus Document Identifier

  • 84862680497

Digital Object Identifier (DOI)

  • 10.1016/j.clinimag.2011.09.014

PubMed ID

  • 22726977

Additional Document Info


  • 36


  • 4