Know thy enemy: Why are tumor-infiltrating regulatory T cells so deleterious? Academic Article uri icon

Overview

abstract

  • We recently described hypoxia as one of the leading mechanism for the recruitment of regulatory T cells (Treg) through CCL28 chemokine in ovarian cancer. Treg promote progression of cancer through tumor-specific immune paralysis but also reprogramming of angiogenesis. We review these mechanisms and discuss the challenges and opportunities for therapy targeting Treg.

publication date

  • July 1, 2012

Identity

PubMed Central ID

  • PMC3382887

Scopus Document Identifier

  • 84874391326

Digital Object Identifier (DOI)

  • 10.4161/onci.19401

PubMed ID

  • 22754792

Additional Document Info

volume

  • 1

issue

  • 4