Extraneural ependymoma: distant bone, lung, liver, and lymph node metastases following bevacizumab. Academic Article uri icon



  • Extraneural metastases of ependymoma are rare, and have been reported in the lungs, lymph nodes, pleura, mediastinum, liver, diaphragmatic muscle, and bone. We report a case of anaplastic ependymoma with distant metastases to the vertebral bones, lungs, liver, and lymph nodes following treatment with bevacizumab. Recent research has hypothesized that angiogenic tumors may develop means of resistance to antiangiogenic therapies, and some evidence suggests potential for antiangiogenic therapies to promote additional means for cancer spread. Nevertheless, antiangiogenic therapies continue to demonstrate potential as potent therapies for the treatment of many cancers, and should continue to be researched for future uses.

publication date

  • September 13, 2012



  • Angiogenesis Inhibitors
  • Antibodies, Monoclonal, Humanized
  • Brain Neoplasms
  • Ependymoma
  • Liver Neoplasms
  • Lung Neoplasms
  • Spinal Neoplasms


Scopus Document Identifier

  • 84870218527

Digital Object Identifier (DOI)

  • 10.1002/pbc.24268

PubMed ID

  • 22976578

Additional Document Info


  • 60


  • 1