Atherogenic low density lipoprotein phenotype in long-term survivors of childhood acute lymphoblastic leukemia. Academic Article uri icon

Overview

abstract

  • Survivors of childhood acute lymphoblastic leukemia (ALL) have an increased risk of cardiovascular disease. Small density lipoproteins are atherogenic but have not been studied in this population. We conducted a cross-sectional analysis of 110 ALL survivors (mean age, 24.3 years) to determine prevalence of small dense LDL (pattern B) phenotype in ALL survivors and identify associated factors. Lipid subfractions were measured using Vertical Auto Profile-II. Participants with greater than 50% of LDL-cholesterol (LDL-c) in small dense LDL fractions (LDL(3+4)) were classified as LDL pattern B. Visceral and subcutaneous adipose tissue (VAT, SAT) volumes were also measured by computed tomography. While the mean LDL-c level of ALL survivors was 108.7 ± 26.8 mg/dl, 36% (40/110) of survivors had atherogenic LDL pattern B. This pattern was more common in males (26/47; 55%) than in females (14/63; 22%, P = 0.001) and more common in survivors treated with cranial radiotherapy (15/33; 45%) than in those who were treated with chemotherapy alone (25/77; 33%; P = 0.04, adjusted for age, gender, history of hypertension, and smoking history). VAT was associated with atherogenic lipids: LDL pattern B and LDL(3+4) levels. This association was independent of other measures of body fat. We conclude that a substantial proportion of ALL survivors had an atherogenic LDL phenotype despite normal mean LDL-c levels. An atherogenic LDL phenotype may contribute to the increase in cardiovascular mortality and morbidity in this population.

publication date

  • September 13, 2012

Research

keywords

  • Lipoproteins, LDL
  • Phenotype
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Survivors

Identity

PubMed Central ID

  • PMC3494249

Scopus Document Identifier

  • 84869020792

Digital Object Identifier (DOI)

  • 10.1194/jlr.P029785

PubMed ID

  • 22984143

Additional Document Info

volume

  • 53

issue

  • 12