5-fluorouracil induced cardiotoxicity: review of the literature. Review uri icon

Overview

abstract

  • 5-fluorouracil (5-FU) is a key chemotherapeutic agent in the treatment of many gastrointestinal tract adenocarcinomas. Despite its proven therapeutic efficacy, 5-FU also possesses several undesired cardiac toxicities, including coronary vasospasm, coronary thrombosis, cardiomyopathy, and sudden cardiac death. This review addresses the incidence, mechanisms of action, clinical presentation, risk stratification, and management of 5-FU associated cardiotoxicity; it also highlights the importance of careful pre-administration cardiac risk stratification and close monitoring during and after drug administration.

publication date

  • January 1, 2012

Research

keywords

  • Antimetabolites, Antineoplastic
  • Fluorouracil
  • Heart Diseases

Identity

Scopus Document Identifier

  • 84867559762

Digital Object Identifier (DOI)

  • 10.5603/cj.2012.0084

PubMed ID

  • 23042307

Additional Document Info

volume

  • 19

issue

  • 5