MRI perfusion in determining pseudoprogression in patients with glioblastoma. Academic Article uri icon

Overview

abstract

  • We examine the role of dynamic susceptibility contrast (DSC) magnetic resonance imaging (MRI) perfusion in differentiating pseudoprogression from progression in 20 consecutive patients with treated glioblastoma. MRI perfusion was performed, and relative cerebral blood volume (rCBV), relative peak height (rPH), and percent signal recovery (PSR) were measured. Pseudoprogression demonstrated lower median rCBV (P=.009) and rPH (P<.001), and higher PSR (P=.039) than progression. DSC MRI perfusion successfully identified pseudoprogression in patients who did not require a change in treatment despite radiographic worsening following chemoradiotherapy.

publication date

  • June 8, 2012

Research

keywords

  • Brain Neoplasms
  • Glioblastoma
  • Magnetic Resonance Angiography
  • Neoplasm Recurrence, Local

Identity

PubMed Central ID

  • PMC4755513

Scopus Document Identifier

  • 84872391677

Digital Object Identifier (DOI)

  • 10.1016/j.clinimag.2012.02.016

PubMed ID

  • 23151413

Additional Document Info

volume

  • 37

issue

  • 1